ROKIT Healthcare introduces the world’s first 3D skin bioprinting platform technology using autologous adipose tissue to regenerate skin while minimizing scar formation.
Adipose tissue is an optimal biomaterial for skin regeneration because adipose tissue contains stromal vascular fraction and extracellular matrix which are two main ingredient in MA-ECM dermis, and 3D bioprinter INVIVO prints minimally processed adipose tissue into a custom shape MA-ECM dermis. Skin regeneration with MA-ECM dermis is achieved by regulating MMPs activity especially MMP13 in both transcription (MT1X, MT2A, MT1E ) and protein level (CEBPB, JUND, EGR2, ZNF117). Also, ECM-M2 macrophage interaction strongly promotes skin regeneration by inducing M2 macrophage to release regenerative cytokines. At the same time, SVF cells from MA-ECM coordinate with M2 macrophage to reorganize the surrounding environment into regenerative condition. Furthermore, MA-ECM bound TIMP3 specifically inactivates MMP13 which is critical in the pathogenic prolongation of chronic wounds. By providing rich ECM originated regenerative environment combined with powerful MMP regulation, ROKIT’s 3D bioprinting MA-ECM skin regeneration platform provides a unique solution to regenerate skin.