ECM (Extracellular Matrix) is a protein complex, consisting of more than 300 proteins, peptides, and polysaccharides. ECM supports cell attachment, proliferation and migration, and it roles as a growth factor reservoir.
A cell culture biomaterial supplement consisting
of full native human ECM (Extracellular Matrix),
useful for in vitro 4D bioprinting
and cell culturing as well as clinical translational studies
HumaTein™
about ECM
What is ECM?
about HumaTein™
What is HumaTein™?
HumaTein™ is a human cell derived whole Extracellular Matrix(ECM), comprised of more than 300 proteins and associated cytokines.
HumaTein™ opens new possibilities for regeneration researches and relative studies.
Applications
2D/3D Culture
Wound Healing
Anti-Aging
HumaTein™ Matrix is an ideal coating material for feeder layer free induced pluripotent stem cell (iPSC) culture. Xeno free and human cell derived Huma Tein is optimized for organoid research.
- Cancer Research
- Stem Cell Research
- Drug Discovery
- Tissue Engineering & Regenerative Medicine
Characteristics
Native whole ECM
Manufacturing processes do not include harsh chemical processing. HumaTein™ preserves whole ECM components.
Organ specific
With ROKIT’s cell sheet technologies, HumaTein™ provides organ specific stiffness controlled environment.
Regeneration
HumaTein™ is applicable for regeneration studies.
In vivo like
environment
Human primary cell derived HumaTein™ provides the most in-vivo like environment to cells, and this enables translational studies.
Custom ECM
With your own cell choice, you can order customized HumaTein™ Special Matrix.
Easy Control
HumaTein™ is not sensitive to temperature changes. It's users friendly texture type.
about HumaTein™
How to use?
Humatein™ Mixture
Humatein™ Hydrogel
Fibroblast Mesenchymal Stem Cells
(primary cells)
(primary cells)
Patient biopsy derived Cells Your Lab Choice Cells
Humatein™ Essential
Humatein™ MSC
Humatein™ Special Matrix
Humatein™ MSC
Humatein™ Special Matrix
Cell Culture Process
Organoid
iPSC Culture
What ROKIT Provides
What ROKIT Supports
Why HumaTein
Regeneration potential of HumaTein
Rapid dermal regeneration & re-epithelialization (9cm x 9cm) within 4 weeks in porcine model
about HumaTein™
How HumaTein™ is made?
HumaTein™ is Isolated from specific native stiffness matching micro-environment grown human cells. HumaTein™ composition is optimized for a target cell type growth and proliferation in a native-like environment.
Cytokine ELISA Array Analysis Comparison
Humatein™ is clinically applicable
99%
Contains 506 essential human Cytokines (SMAD9)
Xenogetic ECM is NOT clinically applicable
73%
Lacks about 27% of cytokines Found in human body
3D Models
Control
Humatein MSC Matrix
A) Phase contrast images of iPSC spheroid.
iPSCs are cultured with MSC-derived HumaTein for a day.
B) Analysis of iPSC spheroid size
Colon organoid using Humatein™ (0.2%)
Actin
Ki-67
DAPI
· Colon organoid with HumaTein™ Essential Matrix (1㎎/㎖)
· Similar size and structure to xenogetic source colon organoid
HumaTein™ Lines
HumaTein™ Lines
HumaTein™ Essential Matrix 50mg
HumaTein™ Essential Matrix 100mg
HumaTein™ Essential Matrix 100mg*5
HumaTein™ MSC Matrix 30mg
HumaTein™ MSC Matrix 60mg
HumaTein™ SPECIAL ORDER 30mg
Catalog#
HT-MD-001-A
HT-MD-001-B
HT-MD-001-C
HT-MD-12
HT-MD-13
HT-CO-01
※ HumaTein™ is provided in mixture and hydrogel types.
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