New Paradigm in Diabetic Foot Ulcer Grafting Techniques Using 3D-Bioprinted Autologous Minimally Manipulated Homologous Adipose
Tissue (3D-AMHAT) with Fibrin Gel Acting as a Biodegradable Scaffold
Author : Mohd Yazid Bajuri, Jeehee Kim, Yeongseo Yu and Muhammad Shazwan Shahul Hameed
Special Issue
Hydrogel-Based Scaffolds with a Focus on Medical Use
Edited by Dr. Federica Re and Dr. Elisa Borsani
Abstract: Adipose tissue is an abundant source of extracellular substances that support the tissue repair process. This pilot study was carried out to determine the efficacy of 3D-bioprinted autologous adipose tissue grafts on diabetic foot ulcers (DFUs), with fibrin gel used to stabilise the graft. This
was a single-arm pilot study in a tertiary hospital that provides diabetic wound care services. A total of 10 patients with a DFU were enrolled, and the primary endpoint was complete healing within 12 weeks. The secondary endpoints were wound size reduction, time to healing, and adverse events. Seven out of ten patients showed complete healing of their DFU within 12 weeks (at 2, 4, 5, 10, and 12 weeks, respectively). The wound size reduction rate was significantly and progressively reduced over time. According to our data, autologous adipose tissue grafting using a 3D bioprinter, with
the addition of fibrin gel that acts as a scaffold, promotes wound healing with high-quality skin reconstruction. Throughout this study period, no adverse events were observed.
Keywords: 3D bioprinter; autologous adipose tissue graft; diabetic foot ulcer; fibrin glue;
biodegradable scaffold; tissue regeneration
Downloads : Skin_DFU Paper_Malaysia_Gels_230110