August 21, 2019 by admin 0 Comments

An interview with Heon Ju Lee on ROCKIT Healthcare’s novel bioprinting treatment for dermal scarring

Authors
Heon Ju Lee
Abstract
In this exclusive interview, Heon Ju Lee discusses ROCKIT healthcare’s novel bioprinting technique used to treat patients with dermal scarring. This interview was conducted by Mike Gregg, Commissioning Editor of the Journal of 3D Printing in Medicine.Dr Heon Ju Lee is the Chief Technology Officer and Managing Director of ROKIT. He is developing the service platform technology for artificial organ regeneration and supervises the overseas business development for the propagation of such service platforms. The focus of these platforms, bringing bio 3D print-based medical therapies into the operating room, on tissues that are relatively easy to fabricate structurally with the current technology, this includes skin, cartilage, hair, retina and heart patch regeneration. Dr Lee has a PhD from MIT in mechanical engineering and has been working as a 3D/4D printing group leader at KIST.

January 1, 2018 by admin 0 Comments

Design, fabrication and evaluation of a hybrid biomanufacturing system for tissue engineering

Authors
Fengyuan Liu
Abstract
Plasma-assisted Bio-extrusion System (PBS System) is an innovative hybrid bio-manufacturing system to produce complex multi-material and functionally graded scaffolds combining multiple pressure-assisted and screw-assisted printing heads and plasma jets. This approach, which represents a step forward regarding the current state of the art technology in the field of biomanufacturing, enables to design and fabricate more effective scaffolds matching the mechanical and surface characteristics of the surrounding tissue, enabling the incorporation of high number of cells uniformly distributed and the introduction of multiple cell types with positional specificity. The system requires complex control software to manipulate different materials, scaffold designs and processing parameters. This software, developed using MATLAB GUI, is detailed in this paper. It provides high freedom of design allowing the users to create single or multi-material constructs with uniform pore size or pores size gradients by changing the operation parameters, such as geometric parameters, lay-down pattern, filament distance, feed rate and layer thickness. Functionally graded scaffolds can also be designed considering different layer-by-layer coating/surface modification strategies using the multi-jet plasma system. Based on the user definition, G programming codes are generated enabling fully integration and synchronization with the hardware of the PBS system. Examples will be provided describing the design of single, multi-material and functionally graded scaffolds.

June 8, 2017 by admin 0 Comments

Biomimetic heterogenous elastic tissue development

Authors
Kai Jen Tsai, Simon Dixon, Luke Richard Hale, Arnold Darbyshire, Daniel Martin & Achala de Mel
Abstract
There is an unmet need for artificial tissue to address current limitations with donor organs and problems with donor site morbidity. Despite the success with sophisticated tissue engineering endeavours, which employ cells as building blocks, they are limited to dedicated labs suitable for cell culture, with associated high costs and long tissue maturation times before available for clinical use. Direct 3D printing presents rapid, bespoke, acellular solutions for skull and bone repair or replacement, and can potentially address the need for elastic tissue, which is a major constituent of smooth muscle, cartilage, ligaments and connective tissue that support organs. Thermoplastic polyurethanes are one of the most versatile elastomeric polymers. Their segmented block copolymeric nature, comprising of hard and soft segments allows for an almost limitless potential to control physical properties and mechanical behaviour. Here we show direct 3D printing of biocompatible thermoplastic polyurethanes with Fused Deposition Modelling, with a view to presenting cell independent in-situ tissue substitutes. This method can expeditiously and economically produce heterogenous, biomimetic elastic tissue substitutes with controlled porosity to potentially facilitate vascularisation. The flexibility of this application is shown here with tubular constructs as exemplars. We demonstrate how these 3D printed constructs can be post-processed to incorporate bioactive molecules. This efficacious strategy, when combined with the privileges of digital healthcare, can be used to produce bespoke elastic tissue substitutes in-situ, independent of extensive cell culture and may be developed as a point-of-care therapy approach.

February 17, 2016 by admin 0 Comments

Application Research of 3D Printing Technology on Dress Forms

Authors
Lim, Hye Won, Cassidy, Thomas and Cassidy, Tracy Diane
Abstract
Dress form is an essential tool in the clothing-making process for pattern block development, draping and quality inspection. However, it is noted that a single dress form is not applicable for a large variety body shapes. There are adjustable dress forms and custom-made dress forms to attempt to make up for the insufficiency of conventional dress forms. However, such types of dress forms are rather costly and their effectiveness is debatable. With this is mind, a customised adjustable kit for the dress form was developed, with the aim to cover different sizes and shapes more precisely. The kit adopts 3D printing technology which enables generating and changing the shape of components efficiently.